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为了进一步改善甾体避孕药的有效性、安全性和可接受性,近年来有人进行了关于甾体避孕药直接经阴道给药的临床研究,结果令人满意。阴道作为性激素的靶器官之一,存在着雌、孕激素受体,能有效地吸收天然和合成的雌、孕激素。有关的动物实验结果显示把含孕激素的硅橡胶埋植剂放人大鼠、家兔的阴道,则孕激素的效能比相同剂量的注射剂至少大6～25倍,比灌饲给药大13～26倍。在妇科临床上常用雌激素制剂直接经阴道给药来治疗因雌激素水平低下所致的各种症状,也有人用孕激素制成阴道坐药来治疗黄体功能不足。含有甾
In order to further improve the effectiveness, safety and acceptability of steroid contraceptives, clinical studies on direct transvaginal administration of steroid contraceptives have been conducted in recent years and the results are satisfactory. Vagina as one of the target organs of sex hormones, there are estrogen and progesterone receptors, can effectively absorb natural and synthetic estrogen and progesterone. Relevant animal experiments show that the progesterone-containing silicone rubber implants released into the vagina of rabbits and rabbits, the progesterone than the same dose of injection at least 6 to 25 times larger than the drug administration of 13 ~ 26 times. In gynecological clinics commonly used estrogen preparations directly transvaginal treatment of estrogen due to low levels caused by a variety of symptoms, some people use vaginal gynecological medicine to treat corpus luteum insufficiency. Contains steroids