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目的:观察乌附麻辛桂姜汤治疗类风湿关节炎(RA)58例(寒湿内蕴型)的临床疗效。方法:选取我院风湿科门诊确诊及住院的RA患者58例(寒湿内蕴型),按照随机数字表法分为观察组和对照组各29例,对照组采用甲氨蝶呤和来氟米特进行治疗,观察组在对照组的基础上采用乌附麻辛桂姜汤进行治疗,比较两组疗效,并观察治疗前后两组患者的风湿三项、血沉、抗环瓜氨酸肽抗体(抗CCP抗体)及血常规、肝功能和肾功能指标的变化,比较两组患者的不良反应情况。结果:治疗后,观察组总有效率96.55%明显高于对照组72.41%(P<0.05)。治疗前两组患者风湿三项、ESR及抗CCP抗体比较无显著差异(P>0.05),治疗后均较治疗前降低(P<0.05),且观察组各项指标改善情况优于对照组(P<0.05)。观察组不良反应率显著低于对照组(P<0.05)。结论:乌附麻辛桂姜汤治疗寒湿内蕴型RA可明显改善风湿三项及ESR和抗CCP抗体指标,安全性高,效果显著。
Objective: To observe the clinical curative effect of Wufumai XGT on 58 cases of rheumatoid arthritis (RA). Methods: Fifty-eight RA patients diagnosed and hospitalized in our department were randomly divided into observation group (n = 29) and control group (n = 29). The control group was treated with methotrexate and fluoride Mitt for treatment, the observation group on the basis of the control group with Wu Fu Matrine and Xin Gui Jiang Tang treatment, the two groups were compared efficacy, and observed before and after treatment in both groups rheumatism, ESR, anti-cyclic citrullinated peptide antibody (Anti-CCP antibody) and blood, liver function and renal function changes, the adverse reactions of two groups were compared. Results: After treatment, the total effective rate in observation group was significantly higher than that in control group (96.55% vs 72.41%, P <0.05). There was no significant difference in ESR and anti-CCP antibody between the two groups before treatment (P> 0.05). After treatment, both of the two groups were significantly lower than before treatment (P <0.05), and the improvement of each index in the observation group was better than that in the control group P <0.05). Adverse reaction rate in observation group was significantly lower than that in control group (P <0.05). CONCLUSION: Wufu Mambo XGG can effectively improve rheumatoid factor, anti-ESR and anti-CCP antibody index in treating RA with high safety and efficacy.