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本文探讨纳洛酮联合精氨酸治疗肝硬化并发肝性脑病的疗效。作者对86例肝硬化并发肝性脑病的患者随机分成观察组和对照组,观察组采用纳络酮加精氨酸,对照组单用精氨酸治疗,其它的综合治疗方法两组相同。对两组临床效果、治疗前后血氨水平、β-内啡肽(β-EP)水平进行比较。结果表明,观察组和对照组的有效率分别为88.3%、58.1%,有显著性差异(P<0.01),两组治疗后β-EP水平有显著性差异(P<0.01)。认为纳洛酮可作为肝性脑病的有效治疗药物之一。
This article investigates the efficacy of naloxone combined with arginine in the treatment of hepatic cirrhosis complicated with hepatic encephalopathy. The authors of 86 patients with cirrhosis complicated with hepatic encephalopathy were randomly divided into observation group and control group, the observation group with naloxone and arginine, the control group with arginine alone, the other comprehensive treatment of the same two groups. The clinical effect, blood ammonia level before and after treatment, β-EP level were compared. The results showed that the effective rate of the observation group and the control group were 88.3% and 58.1%, respectively, with significant difference (P <0.01). There was significant difference (P <0.01) between the two groups after treatment. Naloxone is considered as one of the effective therapeutic agents for hepatic encephalopathy.