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在诊断组织胞浆菌病中,常规使用的血清学试验,由于假阳性和假阴性较多,使其应用受到影响。本文作者报导,利用放射免疫法检测血清和尿标本的荚膜组织胞浆菌抗原。作者检测的尿和血清标本来自以下病人:16例肺外组织胞浆菌培养均阳性的播散性组织胞浆菌病患者,32例阳性培养或血清学试验的自限性组织胞浆菌病患者,32例阳性培养或血清学试验的空洞型组织胞浆菌病患者和8例阳性血清学试验的类肉瘤样综合征患者。对照组包括:30例其它真菌感染,其中4例新型隐球菌,15例白色念珠菌,5例曲菌、3例热带念珠菌,2例皮炎芽生菌和1例短尾帚霉;65例肺部感染,其中军团病11例、结核病18例、奴卡氏菌病2例和细菌性肺炎34例;30例菌血
In the diagnosis of histoplasmosis, routine use of serological tests, due to false positives and false negatives, its application is affected. The authors report the use of radioimmunoassay to detect capsular histoplasma antigen in serum and urine specimens. Urine and serum samples from the authors were obtained from 16 patients with disseminated histoplasmosis positive for extrapulmonary Histoplasmosis and 32 self-limiting histoplasmosis patients for positive culture or serological tests Patients, 32 patients with histoplasmosis in positive cultures or serological tests, and 8 patients with serosarcoma-like syndrome who were serologically tested. The control group consisted of 30 other fungal infections, of which 4 were Cryptococcus neoformans, 15 Candida albicans, 5 Aspergillus species, 3 Candida tropicalis, 2 Diaphorbia germans and 1 Copeplum; 65 Department of infection, including 11 cases of Legionnaires’ disease, tuberculosis in 18 cases, 2 cases of Nocardiosis and bacterial pneumonia in 34 cases; 30 cases of bacteria blood