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目的 研究肿瘤组织中纤溶成份的表达与肿瘤进展和术后生存时间的关系。方法 用Northern印迹和免疫组化法研究 10例正常食管和 4 1例食管癌标本中的尿激酶型纤溶酶原激活物(uPA)、尿激酶型纤溶酶原激活物受体 (uPAR)和纤溶酶激活抑制物 1(PAI 1)。结果 食管癌标本中uPA、uPAR和PAI 1mRNA表达比正常食管分别升高 5 .1,3 .7和 12倍 (P <0 .0 1)。在不同的肿瘤分化程度、不同的TNM分期、不同的组织学类型之间uPA、uPAR和PAI 1的表达差异不显著。肿瘤中uPA和uPAR同步升高的患者与其他患者相比 ,其术后生存时间差异无显著性。结论 本研究表明 ,uPA、uPAR和PAI 1在食管癌组织中均明显升高 ,但这种升高与肿瘤进展和术后生存时间无关。
Objective To study the relationship between the expression of fibrinolytic components in tumor tissue and tumor progression and postoperative survival time. Methods Urokinase-type plasminogen activator (uPA), urokinase-type plasminogen activator receptor (uPAR) in 10 normal esophagus and 41 esophageal cancer specimens were studied by Northern blot and immunohistochemistry. And Plasminogen Activator Inhibitor 1 (PAI 1). Results The expressions of uPA, uPAR and PAI 1 mRNA in esophageal cancer specimens were increased by 5.1, 3.7 and 12 times (P <0.01) respectively. There was no significant difference in the expression of uPA, uPAR and PAI 1 between different tumor differentiation, different TNM stages and different histological types. There was no significant difference in postoperative survival time between patients with synchronous elevated uPA and uPAR in the tumor compared with other patients. Conclusion This study shows that uPA, uPAR and PAI 1 are significantly increased in esophageal cancer tissues, but this increase has no relation with tumor progression and postoperative survival time.