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目的探讨S100A4蛋白在宫颈鳞癌中的表达及其与宫颈鳞癌临床病理特征的关系。方法选取正常的宫颈组织30例和宫颈鳞癌组织93例,用免疫组化SP法对S100A4蛋白在正常宫颈组织和宫颈鳞癌组织中的表达水平进行检测。结果 S100A4蛋白在宫颈鳞癌组织中的阳性表达率显著高于正常宫颈组织,差异有统计学意义(P<0.05)。宫颈鳞癌中S100A4蛋白的表达与临床分期、浸润程度及淋巴结转移有关,在Ⅱ期组织的表达明显高于Ⅰ期组织的表达;在间质浸润≥1/2的表达水平明显高于间质浸润<1/2;有淋巴结转移的患者阳性率明显高于无淋巴结转移患者的阳性率,差异均有显著性(P<0.05)。结论 S100A4蛋白与宫颈鳞癌的发生、临床分期、间质浸润深度及淋巴结转移有关,S100A4的检测有助于预测宫颈鳞癌的浸润、转移,在评价宫颈鳞癌恶性程度和判断预后方面具有一定临床价值。
Objective To investigate the expression of S100A4 in cervical squamous cell carcinoma and its relationship with the clinicopathological features of cervical squamous cell carcinoma. Methods Thirty cases of normal cervical tissue and 93 cases of cervical squamous cell carcinoma were selected. The expression of S100A4 protein in normal cervical tissue and cervical squamous cell carcinoma was detected by immunohistochemical SP method. Results The positive rate of S100A4 protein in cervical squamous cell carcinoma was significantly higher than that in normal cervical tissues (P <0.05). The expression of S100A4 protein in cervical squamous cell carcinoma was correlated with clinical stage, degree of infiltration and lymph node metastasis. The expression of S100A4 protein in stage Ⅱ tissues was significantly higher than that in stage Ⅰ tissues. The expression of S100A4 in interstitial infiltrates was significantly higher than that in stroma The infiltration rate was less than 1/2. The positive rate of patients with lymph node metastasis was significantly higher than that without lymph node metastasis (P <0.05). Conclusion S100A4 protein is associated with the occurrence of cervical squamous cell carcinoma, clinical stage, depth of interstitial infiltration and lymph node metastasis. The detection of S100A4 is helpful to predict the infiltration and metastasis of cervical squamous cell carcinoma, and has certain value in evaluating the malignancy and prognosis of cervical squamous cell carcinoma Clinical Value.