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目的:研究温胃止痛方的药理作用。方法:采用大鼠幽门结扎型胃溃疡、盐酸乙醇型胃溃疡模型观察其对胃溃疡的抑制作用;采用改良酚红含量测定法、小肠炭末推进法观察对正常小鼠胃肠功能的影响;采用化学刺激法研究药物的镇痛抗炎作用。结果:温胃止痛方对大鼠幽门结扎性胃溃疡、盐酸乙醇型胃溃疡具有显著的抑制作用;能抑制正常小鼠胃排空,促进正常小鼠小肠推进功能;对醋酸和甲醛所致小鼠疼痛、醋酸所致小鼠腹腔毛细血管通透性增高具有明显抑制作用。结论:温胃止痛方具有抗溃疡、镇痛、抗炎等药理作用。
Objective: To study the pharmacological effects of Wenwei Zhitong Recipe. Methods: The rat gastric ulcer with pylorus ligation and alcoholic gastric ulcer model were used to observe the inhibitory effect on gastric ulcer. The effects of the modified phenol red content assay and the small intestine carbon propeller method on the gastrointestinal function of normal mice were observed. Study the analgesic and anti-inflammatory effects of drugs by chemical stimulation. Results: Wensheng Zhitong Prescription had a significant inhibitory effect on pylorus-induced gastric ulcer and ethanol-induced gastric ulcer in rats, inhibited gastric emptying in normal mice and promoted small intestine prolapse in normal mice. Rat pain, acetic acid-induced increased peritoneal capillary permeability in mice with significant inhibitory effect. Conclusion: Wenweizhi Tong Fang has anti-ulcer, analgesic, anti-inflammatory and other pharmacological effects.