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目的：观察辛伐他丁治疗高脂血症的效果。方法选择82例原发高脂血症的患者，在治疗前均未使用过降脂类药物，给予辛伐他丁10mg，1次/d，每晚顿服，疗程为8w。于治疗后观察，比较治疗前后的血清TG、TC、HDL-C、LDL-C浓度变化。结果和治疗前对比，TG下降了39.19%,TC下降了23.78%,HDL-C浓度上升了27.54%，LDL-C下降了38.25%；TG、TC、HDL-C、LDL-C有效率分别为78.21%、88.46%、76.51%、80.77%。结论辛伐他丁对于轻中度的原发性高脂血症具有显著的降脂效果，值得在临床上推广使用。“,”Objective To observe the effect of simvastatin treatment hyperlipidemia. Methods Choose 82 cases of patients with primary hyperlipidemia, has not been used before treatment lipid-lowering drugs, ding 10 mg of simvastatin, once per day, every night, clothing, treatment for eight weeks. Observed after treatment, compared before and after treatment serum TG, TC, HDL-C, LDL-C concentration changes. Results Before and treatment, TG decreased by 39.19%, down 23.78% TC, HDL-C concentration increased by 27.54%, LDL-C decreased by 38.25%; TG, TC, HDL-C, LDL-C efficient respectively 78.21%, 88.46%, 70.51%, 80.77%. Conclusion Simvastatin butyl for mild-to-moderate primary hyperlipidemia has significant lipid-lowering effect, is worth popularizing in clinical use.