Copper interactions with DNA of chromatin and its role in neurodegenerative disorders

• 作 者: M. Govindaraju H.S. Shekar S.B
• 机 构: MolecularBiophysicsUnit,DepartmentofPharmacyPractice,DepartmentofPharmaceutics,DepartmentofNeuroscie
• 出 处: 药物分析学报：英文版
• 发表日期: 2013年5期
• 关键词: DNA双螺旋结构 相互作用 神经退行性疾病 铜诱导 染色质 阿尔茨海默氏病 神经系统疾病 浓度依赖性 Human brainChromatinDNACopper
• 基金项目: We thank the Chairman, Prof. S.P. Siddhartha, Molecular Biophysics Unit, Indian Institute of Science, Bangalore, for helpful discussions and valuable comments of this research and sugges- tions. The a

In this study,we have demonstrated the conformational changes to DNA induced by abnormal interactions of copper using circular dichroism,in combination with UV-absorbance and fuorescence spectroscopy.Results confrm that binding of copper to bases of DNA i