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目的探讨培哚普利(雅施达)对老年Ⅰ～Ⅱ级原发性高血压病的疗效。方法选择我院近6年门诊的60例原发性高血压病患者,均服用培哚普利(雅施达),4mg/次,1次/晨,共8周。主要观察治疗前和治疗后第8周末的坐位舒张压。结果Ⅰ-Ⅱ级高血压病人显示两组的血压在治疗后均有显著的下降(P<0.01),而在Ⅰ～Ⅱ级两组间的血压降压效果无显著差异(P>0.05)。治疗过程中未发现严重不良反应事件。结论培哚普利治疗老年Ⅰ～Ⅱ级高血压病的疗效较好而且安全。对于Ⅲ级以上高血压的疗效需进一步探讨。
Objective To investigate the effect of perindopril on senile patients with grade Ⅰ ~ Ⅱ essential hypertension. Methods Sixty patients in our hospital who had been hospitalized in the past 6 years were enrolled in this study. All patients were treated with perindopril, 4mg / time, once daily for 8 weeks. The main observation before treatment and after treatment at the end of the eighth sitting diastolic pressure. Results Patients with grade Ⅰ-Ⅱ hypertension showed a significant decrease in blood pressure after treatment (P <0.01), while there was no significant difference in the effect of blood pressure lowering between the two groups (P> 0.05). No serious adverse events were found during the course of treatment. Conclusion The effect of perindopril in the treatment of elderly patients with grade Ⅰ ~ Ⅱ hypertension is good and safe. The efficacy of hypertension for more than Ⅲ need to be further explored.