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肝脏有代谢、合成、解毒等多种机能,各种检查已有详细报道。但肝切除术、肝移植、休克、多脏器功能不全(MOF)时,可使肝脏承受多大的负荷而产生病态,肝脏有多大程度的贮备力(肝贮备力),尽管这个问题很重要,可是尚无正确指标。作者认为,调控肝能量代谢的肝线粒体机能可用来显示肝机能的贮备力。肝脏多种活动所要求的能量(ATP)大部分由肝线粒体产生。Atkinson提出,肝的能量状态可由能量负荷[(ATP+0.5ADP)/(ATP+ADP+AMP)]表示。研究证实,肝线粒体的活性与线粒体氧化还原状态
Liver metabolism, synthesis, detoxification and other functions, a variety of tests have been reported in detail. However, how much load the liver can bear to produce morbidity and how well the liver has reserve capacity (liver reserve capacity) in liver resection, liver transplantation, shock and multiple organ dysfunction? Although this issue is very important, But there is no correct indicator. The authors suggest that liver mitochondrial function, which regulates liver energy metabolism, may be used to demonstrate liver function reserve. The energy (ATP) required for various activities of the liver is mostly produced by the liver mitochondria. Atkinson suggested that the energy status of the liver can be represented by the energy load [(ATP + 0.5ADP) / (ATP + ADP + AMP)]. Studies confirm that liver mitochondrial activity and mitochondrial redox status