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目的 :证实魏氏伤科热敷治疗床方主要的消肿止痛药理作用 ,了解本方不同制剂对本方的药效影响。方法 :对本方采用混悬剂。酊剂不同提取法制剂制备 ,采用混悬剂灌饲小鼠行扭体法、酊剂外涂鼠尾行甩尾法镇痛试验 ;混悬剂灌饲大鼠行足跖肿胀法、滤纸片致肉芽肿消肿试验。结果 :本方混悬剂制剂有较好的镇痛消肿作用 ,以酒提水沉法疗效较佳 ;本方酊剂冷浸高浓度制剂镇痛作用较好 ,酊剂冷浸低浓度制剂与浓度相近的酊剂热提制剂相比 ,后者镇痛效果较佳。结论 :本方不同提取法制剂以及同一提取法不同浓度制剂对镇痛消肿药效作用可产生不同影响 ,为中药复方剂型改革提供了初步实验依据。
Objective :To confirm the main pharmacological effects of Wei’s injury hot treatment on bed side, to understand the effect of different prescriptions on the efficacy of this side. Method : Use suspension on this side. The preparations of different preparations of tinctures were prepared by the use of a suspension preparation and a writhing method and an external analgesic tailing tailing method. The rats were fed a suspension suspension with a paw edema method and a filter paper-induced granuloma. Detumescence test. RESULTS: The suspension formulation had better analgesic and swelling effect, and the effect of wine lifting and water-sinking method was better. The analgesic effect of cold-soaked high-concentration formulation of this formula was better, and the low-dose preparation and concentration of tincture was cold-soaked. Similar antibacterial heat extract formulations, the latter analgesic effect is better. Conclusion : The effects of different extraction preparations and different concentrations of the same extraction method on the efficacy of analgesic swelling can have different effects, providing preliminary experimental evidence for the reform of traditional Chinese medicine compound prescriptions.