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目的分析梅毒在综合医院住院患者中的患病特点,为防治对策提供科学依据。方法收集贵州地区一家三级甲等综合医院2011年-2013年住院患者梅毒血清学检查(TPPA,RPR)结果以及性别、年龄、职业、住院科室等资料,并对资料进行分析。结果 182 753例住院患者样本,TPPA阳性而RPR阴性的患者梅毒感染率为6.00‰,TPPA和RPR均阳性的患者梅毒感染率为2.17‰。梅毒感染患者中男性886例,女性625例,男女比例为1.42:1,男性梅毒检出率高于女性,不同性别检出率差异有统计学意义(P<0.01)。2011-2013年度住院患者梅毒检出率分别为7.17‰,6.47‰和10.71‰,住院梅毒感染者主要集中在40岁以上人群,占其中22.03‰。结论 2011-2013年度住院患者梅毒感染率有上升趋势,住院患者中梅毒检测TPPA阳性而RPR阴性的患者梅毒感染率比TPPA阳性且RPR阳性的患者梅毒感染率高。临床上需加强对住院患者梅毒血清学的检测,并对梅毒检测TPPA阳性且RPR阴性的患者长期随访,以降低梅毒感染率。
Objective To analyze the prevalence of syphilis among inpatients in general hospitals and provide scientific evidence for prevention and treatment. Methods The data of syphilis serological tests (TPPA, RPR) and sex, age, occupation, hospitalization and other data of hospitalized patients from 2011 to 2013 in a Grade III A general hospital in Guizhou Province were collected and analyzed. Results A total of 182 753 inpatient samples were collected. The prevalence of syphilis was 6.00 ‰ in TPPA-positive and RPR-negative patients, and 2.17 ‰ in patients with positive TPPA and RPR. There were 886 males and 625 females with syphilis infection, the male-female ratio was 1.42: 1. The detection rate of syphilis in males was higher than that in females. There was significant difference between the two sexes (P <0.01). In 2011-2013, the prevalence of syphilis in hospitalized patients was 7.17 ‰, 6.47 ‰ and 10.71 ‰, respectively. Inpatients with syphilis were mainly over 40 years old, accounting for 22.03 ‰ of them. Conclusion The prevalence of syphilis among inpatients in 2011-2013 is on an upward trend. Inpatients with syphilis positive for TPPA and patients with RPR negative syphilis have higher syphilis infection rates than those with TPPA-positive and RPR-positive. Clinical need to strengthen the syphilis serology in hospitalized patients, and syphilis detection of TPPA-positive and RPR-negative patients with long-term follow-up to reduce the syphilis infection rate.