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Objective To evaluate the efficacy and safety of traditional Chinese medicine(TCM)combined with Western medicine in the treatment of patients with common hand,foot and mouth disease(HFMD)by conducting a prospective,controlled,and randomized trial.Methods A total of 452 patients with common HFMD were randomly assigned to receive Western medicine alone(n=220)or combined with TCM(Reduning or Xiyanping injections)(n=232).The primary outcome was the incidence rate of rash/herpes disappearance within 5 days,while secondary outcomes included the incidence rate for fever,cough,lethargy,agitation,and vomiting clearance within 5 days.Results The rash/herpes disappearance rate was 45.5%(100/220)in Western medicine therapy group,and
Objective To evaluate the efficacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in the treatment of patients with common hand, foot and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial. Methods A total of 452 patients with common HFMD were randomly assigned to receive Western medicine alone (n = 220) or in combination with TCM (Reduning or Xiyanping injections) (n = 232). The primary outcome was the incidence rate of rash / herpes disappearance within 5 days, while secondary outcomes included the incidence rate for fever, cough, lethargy, agitation, and vomiting clearance within 5 days. Results The rash / herpes disappearance rate was 45.5% (100/220) in Western medicine therapy group, and