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目的探讨重症监护病房(ICU)经口气管插管患者发生医院感染危险因素及干预对策。方法采用现场调查和回顾性调查方法，对我院ICU收治的经口气管插管抢救时间>48h的110例危重患者进行医院感染因素分析。结果110例经口气管插管患者中发生医院感染42例次，感染率为38.18%；不同基础疾病和不同年龄段医院感染发生率跟年龄、基础疾病、侵入性操作等关系密切。结论 ICU经口气管插管患者医院感染发生率高，应采取行之有效的干预对策，减少经口气管插管患者医院感染的发生。“,”Objective To investigate the ICU (ICU)orotracheal intubation in patients with hospital infection risk factors and countermeasures.Methods Field investigation and retrospective survey method,in ICU of our hospital to orotracheal intubation rescue 110 cases of critically ill patients for longer than 48 hours of factors analysis of nosocomial infection.Results In 110 cases of patients with orotracheal intubation occurred hospital infection in 42 cases.The infection rate was 38.18%;different underlying diseases and different age section of the hospital infection rate with age,underlying diseases, intrusive operation relationship closely.Conclusion ICU after tracheal intubation in patients with hospital infection rate is high,should take effective intervention measures to reduce the incidence of nosocomial infection of patients with orotracheal intubation.