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目的：调查分析ICU清醒患者机械通气期的不良心理反应影响因素及护理干预措施。方法：选取2015年4月~2016年3月在我院ICU行机械通气期的清醒患者86例，分析影响患者不良心理的因素，并对其实施针对性的护理干预措施。三个月后，对比患者护理前后SCL-90的评分情况。结果：ICU清醒患者机械通气期多存在焦虑、抑郁、恐惧、不安全等不良心理，主要原因为插管、环境、年龄、认知等；经过护理后，患者在焦虑、抑郁、敌对、恐惧、躯体化方面的评分明显有所降低，前后比较，差异均具统计学意义（P＜0.05）。结论：ICU清醒患者机械通气期受多种因素影响，心理波动较大，实施针对性的护理干预可以有效改善ICU机械通气患者的心理状态，增强患者的心理健康程度，有利于促进患者早日康复。“,”Objective:To explorer the adverse psychological factors of conscious patients treated by mechanical ventilation and nursing interventions in ICU.Methods:86 patients treated by mechanical ventilation in ICU were selected and randomly selected. After analyzing the adverse psychological factors, scores of SCL-90 were compared before and after the nursing interventions.Results: After the nursing intervention, some indices of scores of SCL-90 was lower than before, and There were statistical significant differences(P<0.05).Conclusion: The targeted nursing intervention could effectively improve the psychological state of conscious patients treated by mechanical ventilation in ICU.