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脾脏的骨髓组织生能为炎性的组织提供稳定的白细胞补充,而白细胞增多与心血管疾病的死亡率是密切相关的。然而,造血干细胞在脾脏中是如何被调控的,这一点至今还没有被清楚地认识。本文研究人员发现,脾脏红髓中的血管细胞粘附分子1阳性的(VCAM1+)巨噬细胞是髓外的骨髓组织生成所必需的,这些巨噬细胞在脾脏中利用粘附分子VCAM-1来滞留造血干细胞。利用纳米颗粒在体RNAi技术,将巨噬细胞集落刺激因子受
Spleen myeloid tissue provides stable leukocyte recruitment to inflammatory tissues, whereas leukocytosis is closely linked to cardiovascular mortality. However, how hematopoietic stem cells are regulated in the spleen has so far not been clearly understood. The researchers found that vascular cell adhesion molecule 1-positive (VCAM1 +) macrophages in spleen red blood cells are required for extramedullary bone marrow tissue production using the adhesion molecule VCAM-1 in the spleen Stranded hematopoietic stem cells. Using nanoparticle in vivo RNAi technology, macrophage colony-stimulating factor is regulated