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多发性骨髓瘤（ MM）是一种血液系统恶性肿瘤，其发病机制涉及骨髓瘤细胞与骨髓微环境间的相互作用、细胞因子的作用以及遗传学异常等方面，目前尚缺乏有效的治疗措施。酪氨酸蛋白激酶／信号传导及转录激活因子（ JAK／STAT）信号通路与 MM 的发生、发展及治疗密切相关。研究JAK／STAT信号通路的组成分子和活化方式，探究该通路信号分子与MM发病以及疾病进展之间的关系将为进一步了解MM的发病机制提供帮助，同时有利于寻找新的药物治疗靶点。“,”Multiple myeloma(MM) is one kind of hematological system malignancies, the pathogenesis of which involves the interaction of myeloma cells and bone marrow microenvironment ,the effects of cytokines and genetic abnormality.Now, MM is short of effective therapeutic measures.Janus kinase/signal transducer and activator of transcription ( JAK/STAT ) pathway is closely correlated with the generation , progress and treatment of MM.Study on the components and activation of JAK/STAT pathway will be helpful to explore the specific mechanisms of MM and find new therapeutic targets .