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目的探讨精液取出后液化10~20 min处理与液化21~30 min处理对人工受精妊娠率的影响。方法选择2011年12月—2015年12月行人工授精助孕的患者,随机分为A组、B组。A组精液处理前液化10~20 min(176 cycle),B组精液处理前液化21~30 min(360 cycle)。比较组间a+b级精子总数、妊娠率及流产率。计量资料比较采用t检验,计数资料比较采用χ~2检验,妊娠率的影响因素采用Logistic多因素回归分析,P<0.05为差异有统计学意义。结果 A组a+b级精子总数[(58.0±38.2)×10~6/ml]低于B组[(66.0±29.4)×10~6/ml]a+b级精子总数。A组妊娠率、流产率分别为21.0%(37/176)、29.7%(11/37),B组分别为16.3%(59/360)、22.0%(13/59),两组比较差异无统计学意义(均P>0.05)。男方年龄、卵泡期用药、非男方因素、处理后a+b级精子总数与妊娠率有关(OR=6.58、4.57、4.13、4.09,均P<0.05)。结论缩短精液处理前液化时间对妊娠率无明显影响。
Objective To investigate the effect of 10 ~ 20 min liquefaction after liquefaction and 21 ~ 30 min liquefaction on the pregnancy rate of artificial insemination. Methods The patients who underwent artificial insemination and pregnancy from December 2011 to December 2015 were randomly divided into A group and B group. Group A was liquefied for 10-20 min (176 cycles) before semen treatment, and Group B was liquefied for 21-30 min (360 cycles) before semen treatment. Group a + b sperm between the total number of groups, pregnancy rate and abortion rate. Measurement data were compared using t test, count data were compared using χ ~ 2 test, pregnancy rate factors using Logistic regression analysis, P <0.05 for the difference was statistically significant. Results The total number of a + b sperm in group A [(58.0 ± 38.2) × 10 ~ 6 / ml] was lower than that in group B [(66.0 ± 29.4) × 10 ~ 6 / ml] The pregnancy rate and abortion rate in group A were 21.0% (37/176) and 29.7% (11/37) respectively in group A, 16.3% (59/360) and 22.0% (13/59) in group B, respectively Statistical significance (all P> 0.05). Male age, follicular phase medication, non-male factors, the total number of a + b sperm after treatment and pregnancy rate (OR = 6.58,4.57,4.13,4.09, both P <0.05). Conclusions Shortening the liquefaction time before semen treatment had no significant effect on pregnancy rate.