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在青春发育期的儿童和成年人,已证明LH以及推测LHRH皆呈脉冲式分泌.但是,大多数研究未能证明9岁以下儿童LH也呈脉冲式分泌.有人曾提出,睡眠期开始呈现周期性的LH分泌是青春期开始的一个生物学指标.但也有一些研究报告,用频繁取血测出在接近青春期的儿童以及青春期前的儿童中,也有呈现脉冲式LH分泌.为解决此疑问.本文使用改良的高敏感度的LH放射免疫分析法,以期阐明在青春期以前的儿童是否存在脉冲式
Children and adults at puberty have demonstrated that both LH and speculated LHRH are pulsatile, but most studies have failed to demonstrate that LH is also pulsatile in children under age 9. It has been suggested that the onset of sleep begins in a period Sexual LH secretion is a biological measure of onset of puberty, but there are also studies that use pulsed LH secretion as evidenced by frequent blood sampling in children near adolescence and pre-puberty. Using a modified high-sensitivity LH radioimmunoassay to clarify whether pre-adolescent children have impulsive