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目的观察米索前列醇用于有高危出血因素分娩中预防产后出血的效果。方法选择有产后出血高危因素分娩者62例,随机分成观察组和对照组,观察组32例,胎儿娩出后宫底注射缩宫素20U、静脉滴注缩宫素20U,同时用米索前列醇400ug纳肛。对照组30例,胎儿娩出后宫底注射缩宫素20U、静脉滴注缩宫素20U,分别观察两组产妇第三产程时间,产后2小时及产后24小时出血量,产后出血的发生率,药物不良反应。结果第三产程时间比较,观察组比对照组短,有显著性差异(P<0.05),产后2小时及24小时出血量,产后出血发生率比较,观察组比对照组低,有显著性差异(P<0.05)。结论在常规使用缩宫素的同时,应用米索前列醇,在有高危出血因素分娩中,预防产后出血临床效果较好,且用药安全、方便。
Objective To observe the effect of misoprostol on the prevention of postpartum hemorrhage during delivery of high risk bleeding factors. Methods 62 cases with high risk of postpartum hemorrhage were randomly divided into observation group and control group. The observation group was 32 cases. The fetus was injected with 20U of oxytocin at the posterior uterus and 20U of oxytocin intravenously. Meanwhile, 400ug of misoprostol Nasi anal. Control group of 30 cases, the fetus after hysteroscopic injection of oxytocin 20U intravenous infusion of oxytocin 20U, were observed in the two groups of maternal third stage of labor time, 2 hours postpartum and postpartum 24 hours bleeding, the incidence of postpartum hemorrhage, drug Adverse reactions. Results Compared with the control group, the observation group was shorter (P <0.05), the amount of bleeding after 2 hours and 24 hours, the incidence of postpartum hemorrhage, the observation group was lower than the control group, there was a significant difference (P <0.05). Conclusions In the routine use of oxytocin, misoprostol is applied. In the delivery of high risk bleeding factors, the clinical effect of preventing postpartum hemorrhage is good and the medication is safe and convenient.