Structure and function of ALG-2,a penta-EF-hand calcium-dependent adaptor protein

• 作 者: Masatoshi MAKI Hironori SUZUKI
• 机 构: DepartmentofAppliedMolecularBiosciences,StructuralBiologyResearchCenter
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2011年8期
• 关键词: 晶体结构分析 钙蛋白酶 ALG 接头 异源二聚体 蛋白相互作用 手型 选择性剪接 ALG-2 calcium penta-EF-hand X-ray cr
• 基金项目: We thank members of the Laboratory of Molecular and Cellular Regulation, Nagoya University Graduate School of Bioagricultural Sciences （MCR-NUGSBS） for their contributions to biochemical and molecular

ALG-2(a gene product of PDCD6) is a 22-kD protein containing five serially repetitive EF-hand structures and belongs to the penta-EF-hand(PEF) family,including the subunits of typical calpains.ALG-2 is the most conserved protein among the PEF family membe