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在体和离体,观察了利多卡因对大鼠胃电和胃运动的影响。在整体实验中,用不锈钢双极电极引导胃电,用橡皮囊换能器法记录胃的运动;在离体实验中,用银丝吸附电极引导胃电,以应变规法记录胃的运动。结果表明,利多卡因对在体和离体胃的电活动和运动均有兴奋效应。此效应不受溴化六甲双铵和阿托品的影响。提示,利多卡因对胃电和胃运动的兴奋效应是对胃平滑肌的直接作用,与神经无关。
In vivo and ex vivo, the effects of lidocaine on gastric electrophysiology and gastric motility in rats were observed. In the whole experiment, stomach electroporation was guided by a stainless steel bipolar electrode, and the movement of the stomach was recorded by a rubber bag transducer method. In an ex vivo experiment, stomach electricity was guided by a silver-wire-adsorbing electrode, and the movement of the stomach was recorded by a strain gauge method. The results showed that lidocaine has stimulatory effects on electrical activity and movement in both body and ex vivo stomachs. This effect is not affected by hexamethylene diammonium bromide and atropine. It is suggested that the stimulatory effect of lidocaine on gastric motility and gastric motility is a direct effect on gastric smooth muscle and has nothing to do with nerves.