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为了探讨与膀胱癌发生危险有关的谷胱甘肽S -转移酶 (GSTs)M 1和T1基因型的多态性在有联苯胺接触的膀胱癌高危人群中的分布状况 ,对上海市染料化工行业的联苯胺接触人群与上海市某制造行业的健康对照人群作各种基因型构成比的比较 ,在接触人群中进行工种和工龄的职业因素分层分析。结果表明 ,接触人群中T10 / 0型、M 10 / 0型、和T10 / 0 -M10 / 0型的构成比均高于对照人群 ,在T10 / 0 -M10 / 0型的构成比上出现统计学意义 (OR =1 5 8,χ2 =5 41)。职业因素分层分析未发现显著的趋势或差异。结果中 ,职业性膀胱癌高危人群中GSTs 0 / 0基因型的构成比向高比例方向移动可以理解。但研究中该人群虽是一个特殊职业人群 ,可从根本上说仍应属于健康人群 ,而健康人群中GSTs 0 / 0基因型的构成比会产生漂移 ,在过去的研究中尚未见过。联苯胺的接触强度和接触程度未影响整个接触人群GSTs 0 / 0基因型的构成比漂移的基本情况 ,可佐证化学致癌过程无阈值的理论
To investigate the distribution of M 1 and T 1 polymorphisms of glutathione S - transferase (GSTs) associated with the risk of bladder cancer in high risk population of bladder cancer with benzidine exposure, Industry benzidine exposure to a manufacturing industry in Shanghai and healthy control population for various genotypes comparisons, occupational exposure in the population and occupation length of occupation factors stratified analysis. The results showed that the proportions of T10 / 0, M10 / 0 and T10 / 0-M10 / 0 in the exposed group were higher than those in the control group, and there were statistics on the ratio of T10 / 0-M10 / 0 Significance (OR = 158, χ2 = 5 41). Hierarchical analysis of occupational factors found no significant trends or differences. As a result, it is understandable that the constitution of GSTs 0/0 genotype in high-risk population of occupational bladder cancer is higher than that in high proportion. However, although the population was a special occupational group in the study, it should be fundamentally still belonged to the healthy population. However, the proportion of GSTs 0/0 genotype in healthy population would drift, which has not been seen in the past studies. The contact strength and the contact degree of benzidine did not affect the basic situation of the compositional ratio drift of GSTs 0/0 genotypes in the whole contact population, which could be proved that there is no threshold theory of chemical carcinogenesis