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目的 探讨血浆一氧化氮（ＮＯ） 和内皮素（ＥＴ） 在婴幼儿肺炎呼吸衰竭发生发展中的作用。方法 本题采用生化Ｇｒｉｅｓｓ 法和放免法测定ＮＯ 和ＥＴ 的含量变化以及研究了二者与小儿危重评分的关系。结果 肺炎呼衰患儿血浆ＮＯ 值减少，血浆ＥＴ 值增加，Ⅱ型呼衰ＥＴ 值增加较Ⅰ型呼衰更为显著；小儿危重评分的分值越小，血浆ＮＯ 的水平越低，血浆ＥＴ 的水平就越高。结论 血浆ＮＯ 和血浆ＥＴ 参与肺炎呼吸衰竭的发生发展，二者与疾病的危重程度一致
Objective To investigate the role of plasma nitric oxide (NO) and endothelin (ET) in the occurrence and development of respiratory failure in infants with pneumonia. Methods This study used biochemical Griess method and radioimmunoassay determination of NO and ET content changes and the relationship between the two and children’s critical mass score. Results In children with pneumonia and respiratory failure, the plasma NO level decreased, the plasma ET increased, the type II respiratory failure increased more significantly than the type Ⅰ respiratory failure. The smaller the score of pediatric critical score, the lower the plasma NO level. The plasma ET The higher the level. Conclusions Plasma NO and plasma ET are involved in the development of respiratory failure in pneumonia, both of which are consistent with the severity of the disease