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AIM:Candida esophagitis is a frequent infection inimmunocompromised patients.This study was designed todetermine its characteristics in non- human immune deficiencyvirus (HIV) infected patients attending a teaching hospital.METHODS:Clinical records of all patients coded byinternational classification of diseases 9th revision withclinical modifications’ (ICD-9-CM),with candida esophagitisdiagnosed by esophagogastroduodenoscopy (EGD) andhistopathology over a period of 5 years were studied.RESULTS:Fifty-one patients (27 males,24 females,range21-77 years old and mean age 52.9 years) fulfilled the criteria(0.34% of the EGD).The common predisposing factorswere carcinoma (OR 3.87,CI 1.00-14.99) and diabetesmellitus (OR 4.39,CI 1.34-14.42).The frequent clinicalsymptoms were retrosternal discomfort,dysphagia andepigastric abdominal pain with endoscopic appearance ofscattered mucosal plaques.Another endoscopic lesion wasassociated with candida esophagitis in 15% patients.CONCLUSION:Carcinomas,diabetes mellitus,corticosteroidand antibiotic therapy are major risk factors for candidaesophagitis in Pakistan.It is an easily managed complicationthat responds to treatment with nystatin.
AIM: Candida esophagitis is a frequent infection in immunocompromised patients. This study was designed todetermine its characteristics in non-human immune deficiency virus (HIV) infected patients attending a teaching hospital. METHODS: Clinical records of all patients coded by international classification of diseases 9th revision with clinical changes (ICD-9-CM), with candida esophagitis diagnosed by esophagogastroduodenoscopy (EGD) and histopathology over a period of 5 years were studied .RESULTS: Fifty-one patients (27 males, 24 females, range21-77 years old and mean age 52.9 years The common predisposing factorswere carcinoma (OR 3.87, CI 1.00-14.99) and diabetesmellitus (OR 4.39, CI 1.34-14.42). The frequent clinical changes were retrosternal discomfort, dysphagia andepigastric abdominal pain with endoscopic appearance of scattered mucosal plaques. Additional endoscopic lesion wasassociated with candida esophagitis in 15% patients. CONCLUSION: Carcinomas, di abetes mellitus, corticosteroid and antibiotic therapy are major risk factors for candidaesophagitis in Pakistan. It is an easily managed complication of responds to treatment with nystatin.