论文部分内容阅读
目的:探讨转化生长因子-β1(TGF-β1)与雄激素受体(AR)和雌激素受体α(ERα)在前列腺癌(PCA)中表达的相互作用及意义。方法:应用免疫组织化学染色法检测76例PCA组织中TGF-β1、AR、ERα的表达及分布情况,并与30例良性前列腺增生(BPH)组织进行对照分析。结果:TGF-β1、AR与ERα在PCA组织中的阳性表达率分别为72.37%、81.58%和59.21%,与BPH组织(43.33%、33.33%和16.67%)相比,差异有统计学意义,P<0.01。TGF-β1和AR与肿瘤的病理分级存在相关性,P<0.01,而ERα与肿瘤的病理分级无明显关系,P>0.05。PCA组织中,TGF-β1与AR的表达呈正相关(P<0.01),与ERα的表达无相关性(P>0.05);在BPH组织中两者均无相关性。结论:TGF-β1、AR和ERα均参与了前列腺组织恶性转化的过程,且与癌细胞的分化程度存在密切联系。在PCA进展过程中,TGF-β1与AR发挥着协同促癌作用,而与ERα发挥着或协同或拮抗的效应。
Objective: To investigate the interaction between transforming growth factor-β1 (TGF-β1) and androgen receptor (AR) and estrogen receptor α (ERα) in prostate cancer (PCA). Methods: The expression and distribution of TGF-β1, AR and ERα in 76 cases of PCA were detected by immunohistochemical staining and compared with that of 30 cases of benign prostatic hyperplasia (BPH). Results: The positive rates of TGF-β1, AR and ERα in PCA tissues were 72.37%, 81.58% and 59.21%, respectively, which were significantly different from those of BPH tissues (43.33%, 33.33% and 16.67% P <0.01. There was a correlation between TGF-β1 and AR and pathological grade of tumor (P <0.01), but there was no significant relationship between ERα and pathological grade of tumor (P> 0.05). In PCA, the expression of TGF-β1 was positively correlated with AR (P <0.01), but not with the expression of ERα (P> 0.05). There was no correlation between TGF-β1 and AR in PCH. Conclusion: TGF-β1, AR and ERα are involved in the process of malignant transformation of prostate tissue, and are closely related to the degree of differentiation of cancer cells. In the process of PCA, TGF-β1 and AR play a synergistic role in carcinogenesis, and play a synergistic or antagonistic effect with ERα.