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本文研究硒缺乏对动物心肌损伤的影响，借以探讨硒缺乏和克山病的关系．采用低硒的合成饲料喂养五周龄ＢＡＬＢ／Ｃ雄性小鼠五周，测定全血中的谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性及肝脏中硒的含量，用光镜和电镜观察心肌的病变．实验结果表明缺硒组小鼠全血中ＧＳＨ－Ｐｘ活性及肝硒值明显低于对照组（Ｐ＜０．０１），成功地复制出缺硒动物模型．
This paper studies the effects of selenium deficiency on animal myocardial injury in order to explore the relationship between selenium deficiency and Keshan disease. The five-week-old male BALB / C mice were fed with low-selenium diet for five weeks to determine the activity of glutathione peroxidase (GSH-Px) in the whole blood and the content of selenium in the liver. Observation of myocardial lesions. The experimental results showed that GSH-Px activity and hepatic selenium in the whole selenium-deficient mice were significantly lower than those in the control group (P <0.01), and selenium-deficient animal models were successfully replicated.