Effects of dl-3-n-butylphthalide on region al cerebral blood flow in right middle cerebra

• 作 者: 阎超华 冯亦璞 张均田
• 机 构: 协和医科大学中国医学科学院药物研究所
• 出 处: Acta Pharmacologica Sinica
• 发表日期: 1998年02期
• 关键词: occlusion 丁基苯酞 artery blood cerebral flow in middle Effects of

目的：观察ｄｌ３ｎ丁基苯酞（ＮＢＰ）对右大脑右中动脉阻断（ＲＭＣＡＯ）大鼠缺血区局部脑血流（ｒＣＢＦ）的影响．方法：氢清除法动态监测ＲＭＣＡＯ大鼠ｒＣＢＦ变化．结果：ＲＭＣＡＯ后１０ｍｉｎｉｐＮＢＰ（５，１０，２０ｍｇ·ｋｇ－１）可明显增加ｒＣＢＦ（与溶剂对照组相比Ｐ＜００１），４０ｍｉｎ给药有类似作用但作用较弱（与给药前相比Ｐ＜００５），６０ｍｉｎ给药不能增加ｒＣＢＦ（与给药前相比Ｐ＞００５）．此外，ＲＭＣＡＯ前４０ｍｉｎｉｐＮＢＰ也可使ＲＭＣＡＯ后不同时间点ｒＣＢＦ明显增加．尼莫地平（０５ｍｇ·ｋｇ－１，ｉｐ）与ＮＢＰ（１０ｍｇ·ｋｇ－１，ｉｐ）具有相似的作用．结论：ＮＢＰ预防给药或治疗给药能使ＲＭＣＡＯ后减少的ｒＣＢＦ明显增加．

Objective: To observe the effects of dl3nbutylphthalide (NBP) on ischemic regional cerebral blood flow (rCBF) in right middle cerebral artery occlusion (RMCAO) rats. Methods: The dynamic changes of rCBF in RMCAO rats by hydrogen scavenging assay. Results: 10 minipNBP (5, 10, and 20 mg · kg -1) significantly increased rCBF after RMCAO (P <001 compared with the solvent control group), but had similar effects but weaker action at 40 min P <005), rCBF was not increased after 60min administration (P> 005). In addition, rMCAO 40minipNBP before RMCAO also make rCBF significantly increased at different time points after RMCAO. Nimodipine (05 mg · kg-1, ip) had a similar effect with NBP (10 mg · kg-1, ip). CONCLUSIONS: NBP prophylaxis or treatment administration significantly reduced rCBF after RMCAO.