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采用同步脑电与功能磁共振(Simultaneous electroencephalography-correlated functional magnetic resonance imaging,EEG-fMRI)技术,研究青少年肌阵挛癫痫患者发作间期痫样放电时脑部血氧水平依赖(Blood oxygen level-dependent,BOLD)信号变化。结果发现:双侧大脑半球的激活及失活信号变化普遍对称且各自独立存在,信号由枕顶至额区逐渐减少。阳性激活区有:楔叶、岛叶、额中部内侧、小脑中线两侧及丘脑。阴性激活区有:双侧额前部、顶部及扣带后回。由此推断:以棘慢复合波为表现形式的同步的神经元活动可能反映了丘脑皮层BOLD信号的激活,而失活区域反映了异常放电时的脑功能的静息状态;这类激活在神经元的活动(EEG)与fMRI结果之间有很好的对应关系;EEG-fMRI是研究脑功能状态有效的方式。
Simultaneous electroencephalography-correlated functional magnetic resonance imaging (EEG-fMRI) was used to study the effects of blood oxygen level-dependent (ERP) on epileptiform discharge during interictal seizures in adolescents with myoclonic epilepsy. , BOLD) signal changes. The results showed that the activation and inactivation signals of bilateral cerebral hemispheres were generally symmetrical and independent of each other, and the signal gradually decreased from the top of the pillow to the frontal area. Positive activation areas are: wedge leaves, insula, medial frontal middle, both sides of the cerebellar midline and the thalamus. Negative activation area: frontal bilateral front, top and cingulate back. It is inferred that synchronized neuronal activity in the form of spike-slow complex may reflect the activation of BOLD signaling in the thalamic cortex while the inactivated region reflects the resting state of brain function during abnormal discharge; There is a good correspondence between the meta-activity (EEG) and fMRI results; EEG-fMRI is an effective way to study the state of brain function.