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二萜类化合物银杏内酯是银杏中具有药理作用的活性成分。法国出售的商品名为Tanakan的银杏叶提取物,据介绍用于治疗脑血管疾病和老年痴呆。最近的研究表明,银杏内酯B是强血小板活化因子(PAF)拮抗剂,由此可证明它对治疗气喘病、内毒素休克、移植感染上有效。过去测定银杏叶提取物中的银杏内酯的薄层层析法,由于缺乏灵敏度和专属性,一直不能令人满意。如Lobstein-Guth法,银杏内酯B的最小检出量为30μg,因此不适于提取物中银杏内酯的测定。用本法最小检出量可降至4μg。
The diterpenoid compound ginkgolide is a pharmacological active ingredient in ginkgo biloba. The French Ginkgo biloba extract, sold under the trade name Tanakan, is described for the treatment of cerebrovascular disease and Alzheimer’s disease. Recent studies have shown that ginkgolide B is a potent platelet-activating factor (PAF) antagonist, which may prove to be effective in the treatment of asthma, endotoxin shock, and graft infection. In the past, thin layer chromatography for the determination of ginkgolide in Ginkgo biloba extract has been unsatisfactory due to lack of sensitivity and specificity. As the Lobstein-Guth method, the minimum detectable amount of ginkgolide B is 30 μg, so it is not suitable for the determination of ginkgolides in extracts. With this method, the minimum detection amount can be reduced to 4μg.