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目的:研究血管生成素-2(Ang-2)蛋白在人大肠癌组织中的表达及其与大肠癌临床病理特征的关系。方法:应用免疫组化法检测40例大肠癌及其癌旁正常组织中Ang-2蛋白表达水平。结果:大肠癌组织中Ang-2蛋白表达阳性率77.5%(31/40),明显高于癌旁正常组织40%(16/40)(P<0.01);Ang-2表达水平与患者性别、年龄及癌组织的部位、大小、分化程度、淋巴结转移无关(P>0.05);隆起型大肠癌Ang-2蛋白表达水平高于溃疡型大肠癌(P<0.01);肠壁浸润越深,Ang-2蛋白表达水平越高(P<0.01);有血道转移的比无血道转移的Ang-2表达水平高(P<0.05);Dukes分期D期Ang-2蛋白表达水平明显高于A期(P<0.01)。结论:Ang-2蛋白表达水平与大肠癌组织大体形态、浸润深度、血道转移及Dukes分期有关,提示Ang-2蛋白可能促进了大肠癌的生长及转移。
Objective: To study the expression of angiopoietin-2 (Ang-2) protein in human colorectal cancer and its relationship with clinicopathological features of colorectal cancer. Methods: Immunohistochemical method was used to detect the expression of Ang-2 protein in 40 cases of colorectal cancer and adjacent normal tissues. Results: The positive rate of Ang-2 protein expression in colorectal cancer tissues was 77.5% (31/40), which was significantly higher than that in adjacent normal tissues (40%, 16/40) (P<0.01). The expression level of Ang-2 and patient gender, There was no correlation between age, cancer tissue location, size, differentiation, and lymph node metastasis (P>0.05). The expression of Ang-2 protein in colorectal cancer was higher than that in ulcerous colorectal cancer (P<0.01). The deeper the intestinal wall infiltration, Ang The higher the expression of -2 protein (P<0.01), the higher the level of Ang-2 with hematogenous metastasis than that without hematogenous metastasis (P<0.05), and the higher expression level of Ang-2 protein in Dukes stage D than that of stage A (P<0.05). P<0.01). Conclusion: The expression of Ang-2 protein is related to the gross morphology, depth of invasion, hematogenous metastasis and Dukes stage of colorectal cancer, suggesting that Ang-2 protein may promote the growth and metastasis of colorectal cancer.