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华法林属于香豆素类抗凝药,是目前全球应用最为广泛的口服抗凝药物。广泛应用于肺栓塞、心脏金属瓣膜置换术后、房颤、下肢深静脉血栓的抗凝治疗~([1])。华法林疗效被广泛认可,但其治疗窗较窄,个体差异较大,其较窄的治疗窗指数以及抗凝不当导致的严重并发症长期阻碍临床推广。影响华法林疗效的因素包括患者性别、身高、体质量、肝肾功能、营养情况、
Warfarin belongs to coumarin anticoagulant, which is currently the most widely used oral anticoagulant in the world. Widely used in pulmonary embolism, cardiac valve replacement, atrial fibrillation, anticoagulation of deep venous thrombosis ~ ([1]). Warfarin efficacy is widely recognized, but its therapeutic window is narrow, the individual differences are larger, and its narrow therapeutic window index and serious complications caused by improper anticoagulation have long hindered the clinical promotion. Factors affecting warfarin efficacy include patient gender, height, weight, liver and kidney function, nutritional status,