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生长因子通过与细胞膜相应受体的特异性高亲和力结合,增强肿瘤细胞生长与迁移能力,促进肿瘤组织中血管生成,诱导肿瘤组织周围微环境改变,调节患者免疫应答功能,在肿瘤发生、发展中起重要作用。表皮生长因子及其受体、转化生长因子及其受体、胰岛素样生长因子家族、血管生成因子等是潜在的乳腺癌转移预后的血清标志物,有望用于判断转移状态、监测治疗效果和预测患者预后。联合检测血清中在乳腺癌进展和转移过程中有协同作用或相互影响的生长因子和生长因子受体的水平,有望提高判断乳腺癌转移和预测患者预后准确性,并将为乳腺癌血清标志物研究和应用奠定基础。
Growth factors bind to specific receptors of cell membranes with high specific affinity to enhance tumor cell growth and migration, promote angiogenesis in tumor tissues, induce microenvironmental changes in tumor tissues, and modulate immune response functions in patients. makes an important impact. Epidermal growth factor and its receptors, transforming growth factor and its receptors, insulin-like growth factor family, angiogenic factors, etc. are potential serum markers of metastasis and metastasis of breast cancer, and are expected to be used to judge metastasis status, monitor therapeutic effect, and predict prognosis. Patient prognosis. Combined detection of serum levels of growth factors and growth factor receptors in the progression and metastasis of breast cancer during progression and metastasis is expected to improve the accuracy of predicting breast cancer metastasis and predict patient prognosis, and will be a marker for breast cancer serum Lay the foundation for research and application.