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本文报道皮肤接触和蒸气吸入杂酚油(一种木材防腐剂),可引起接触性皮炎和光敏作用,还可致皮肤癌。最近有报告用细菌检测杂酚油无致突变作用。为此,作者采用沙门氏菌/微粒体试验再检测杂酚油的致突变性。按Ames等(1975)方法,采用鼠伤寒沙门氏菌TA_(1535)、TA_(1537)、TA_(1638)、TA_(98)和TA_(100)五个菌株。在另一实验中每皿加环氧化物水解酶的抑制剂1,2-环氧-3,3,3-三氯丙烷(TCPO)2.3μM。实验结果表明,除TA_(1535)菌株对杂酚油不
This article reports skin contact and vapor inhalation of Creosote (a wood preservative) that can cause contact dermatitis and photosensitization but can also cause skin cancer. Recent reports of bacterial detection of creosote no mutagenic effect. To this end, the authors used Salmonella / microsome tests to test the mutagenicity of creosote. According to the method of Ames et al. (1975), five strains of Salmonella typhimurium TA_ (1535), TA_ (1537), TA_ (1638), TA_ (98) and TA_ (100) In another experiment, an inhibitor of epoxide hydrolase 1,2-epoxy-3,3,3-trichloropropane (TCPO) 2.3 μM was added to each dish. The experimental results show that, except TA_ (1535) strain of creosote not