【摘 要】
：
A new Hairless (Hr) gene mutant mouse line (SHJHhr) was identified,which showed hairless skin in adult individuals as reported in rhino mice.Through Hr gene mutant identification with polymerase chain reaction (PCR) amplification and sequencing,seven muta
【机 构】
：
Guangdong Provincial Key Laboratory of Laboratory Animals,Guangdong Laboratory Animals Monitoring In
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A new Hairless (Hr) gene mutant mouse line (SHJHhr) was identified,which showed hairless skin in adult individuals as reported in rhino mice.Through Hr gene mutant identification with polymerase chain reaction (PCR) amplification and sequencing,seven mutants were identified,including nonsense mutant site 2134C→T (R467X),which produced a truncated Hr protein.Metabolic activity and heart rate were measured using a metabolic cage and blood pressure instrument,respectively.The SHJHhr mice showed a strong metabolic rate,high heart rate,and low blood pressure.Histological analysis of the thyroid gland of SHJHhr mice showed abnormal follicular structure and hypertrophic thyrocytes.Compared to ICR mice,thyroid function in 4-month-old SHJHhr mice showed lower thyroid stimulating hormone (TSH) levels,and in 9-month-old SHJHhr mice showed significantly higher TSH and thyroid hormone levels.These data indicate that SHJHhr mice may be in a hyperthyroid state with increasing age.Thus,based on the above results,we successfully established a novel mouse model with thyroid dysfunction.
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