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目的：为研究代谢型谷氨酸受体在中枢神经系统内的功能作用提供形态学依据．方法：用免疫组织化学技术，在光学显微镜下观察代谢型谷氨酸受体7亚型（mGluR7）在大鼠脑和脊髓内的分布．结果：mGluR7阳性浓染的神经元胞体和纤维主要密集分布于Calleja岛、海马、齿状回、内侧级核、橄榄顶盖前核、上丘带状层、三叉神经尾侧亚核浅层、三叉旁核、中缝大核、中缝苍白核、蓝斑、脊髓背角浅层和外侧脊核．呈中等强度染色的神经元胞体和纤维见于嗅结节、前嗅核、梨状皮质、隔伞核、终纹床核、下丘脑外侧区、下丘脑室旁核、乳头体上核、乳头体内、外核、丘脑大部分校团、内外侧膝状体、视束核、红核、黑质、脚间核、桥核、臂旁外侧核、上橄榄复合体、斜方体核、三叉神经运动核、面神经核、疑核、耳蜗核、前庭核簇、楔束外核、孤束核、舌下神经核、舌下神经前置核、中缝隐核、延髓网状结构、小脑蒲肯野细胞层、脊髓中间带外侧核、Onuf核和中央管周围灰质．此外，在许多脑区还可见淡染的和散在分布的阳性胞体和纤维结论：mGluR7广泛分布于大鼠中枢神经系统内，提示它在谷氨酸引起的兴奋性信息传递中可能起着重要作用．
OBJECTIVE: To provide a morphological basis for studying the functional role of metabotropic glutamate receptors in the central nervous system. Methods: Immunohistochemistry was used to observe the distribution of metabotropic glutamate receptor subtype 7 (mGluR7) in rat brain and spinal cord under optical microscope. Results: The mGluR7-positive neurons and fibers were densely distributed on the island of Calleja, hippocampus, dentate gyrus, medial side nucleus, olivopancreatic prolapse nucleus, superior colliculus, superficial layer of the trigeminal nerve, Trigeminal nucleus, stapes, stapes, melasma, superficial and lateral spinal nuclei of spinal dorsal horn. Moderate-intensity staining of neuronal somatic cells and fibers found in the olfactory nodules, pre-olfactory nucleus, piriform cortex, septal nucleus, striation nucleus, hypothalamic lateral zone, hypothalamic paraventricular nucleus, papillary body nucleus, nipple , Most of the outer nucleus, the thalamus, the medial and lateral geniculate nucleus, the optic tract nucleus, the red nucleus, the substantia nigra, the interventricular nucleus, the bridge nucleus, the paravertebral lateral nucleus, the olivary complex, the rhizopus nucleus, the trigeminal nerve Nucleus accumbens, nuclear, facial nucleus, nucleus accumbens, cochlear nucleus, vestibular nucleus tufts, outer nucleus of wedges, nucleus tractus solitarius, hypoglossal nucleus, hypoglossal presynaptic nucleus, The cytoplasmic layer, lateral medulla oblongata nucleus, Onuf nucleus and periaqueductal gray matter. In addition, light and scattered positive cell bodies and fibers were also seen in many brain regions. Conclusion: mGluR7 is widely distributed in the central nervous system of rats, suggesting that mGluR7 may play an important role in the glutamate-induced excitatory message transmission .