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已经证明，双着丝粒畸变分析可应用于辐射生物剂量学的许多场合，如细胞遗传学与物理学方法结合可用来估算最近发生的严重过量照射。对于内科医生来说，剂量信息是很重要的，因剂量可能和随机或确定的健康风险有关。讨论了一种新近发展的用来观察稳定性易位的荧光原位杂交（ＦＩＳＨ）法及其作为回顾性剂量计应用的有关课题，如一次全身均匀照射后１１ 年获得可信的剂量估算。值得注意的是，离体实验表明，非均一或局部照射可能导致易位率随时间降低。最后对ＦＩＳＨ法所要求的工作量和其对低剂量的分辨能力的局限性进行了评论，这是在发生广泛的核素环境污染后用该方法进行人群的回顾性剂量评估所必须考虑的。
It has been demonstrated that dicentric distortion analysis can be applied to many applications of radiation biometrics, such as cytogenetics combined with physical methods to estimate recent severe overdoses. For physicians, dosage information is important because the dose may be related to a random or defined health risk. A newly developed fluorescence in situ hybridization (FISH) method for observing stability translocations and related topics for retrospective dosimetry applications are discussed, such as a credible dose estimation of 11 years after a uniform whole body irradiation. It is noteworthy that the in vitro experiments show that non-uniform or local irradiation may lead to decreased translocation over time. Finally, the amount of work required by the FISH method and its limitations on the resolution of low doses were reviewed, which must be considered in retrospective dose assessment of populations using this method after widespread environmental contamination of the nuclei.