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目的:探讨无创血流动力学监测系统（NICaS）监测急性中重度农药中毒患者的血流动力学方法，分析NICaS在急性中重度农药中毒患者血流动力学的临床指导价值。方法:于2019年8月，选取2017年1月至2019年8月收住哈励逊国际和平医院的急性重度有机磷农药中毒（AOPP）患者和中-重型急性百草枯农药中毒（APP）患者，共200例作为研究对象，将其随机分为NICaS组68例、经肺热稀释法组（Picco组）67例、经验治疗组（经验组）65例。分析3组患者急性生理学和慢性健康评分（APACHEⅡ）、心率、血流动力学指标、生存率和并发症的关系。结果:NICaS组、Picco组和经验组患者年龄、性别构成比、体重指数、心率、收缩压、无治疗期及入院APACHEⅡ评分差异均无统计学意义（n P>0.05）；与经验组比较，NICaS组、Picco组患者AOPP及APP住院病死率均较低，差异均有统计学意义（n P<0.05）。心排出量（CO）在2.8~6.7 L·minn -1的相关性明显（n r=0.738，n r2=0.545，n P<0.01），外周血管阻力指数（SVRI）在410~1 950 d·s·cmn -5·mn 2的相关性明显（n r=0.792，n r2=0.627，n P<0.01）。Bland-Altmen分析显示，Picco和NICaS法所测得CO和SVRI值分别具有97.01%、95.52%的一致性。与经验组比较，NICaS组和Picco组患者平均每日输液量、每日输注胶体液量均较低，差异均有统计学意义（n P<0.05），各组间获得CO时间差异均有统计学意义（n P0.05) ; Compared with the experience group, the mortality of AOPP and app in NICaS group and Picco group were lower, and the differences were statistically significant (n P<0.05) .The cardiac output (CO) had a significant correlation in the interval of 2.8-6.7 L·minn -1 (n r=0.738, n r2=0.545, n P<0.01) , and peripheral vascular resistance index (SVRI) had a significant correlation in the interval of 410-1 950 d·s·cmn -5·mn 2 (n r=0.792, n r2=0.627, n P<0.01) . Bland Altman analysis showed that CO and SVRI measured by Picco and NICaS had 97.01% and 95.52% consistency, respectively. Compared with the experience group, the average daily infusion volume and daily colloid infusion volume of NICaS group and Picco group were lower, the differences were statistically significant (n P<0.05) .n Conclusion:NICaS can effectively monitor the hemodynamic indexes of patients with acute pesticide poisoning.