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青霉素經口应用的效力早已是確定無疑了。但在某些情况下口腔粘膜对青霉素却極为敏感。青霉素(及鏈霉素)能引起多种多样的过敏性表現(荨麻疹、剝脱性皮炎)。当“含服”青霉素錠及其他方式的局部应用時,則口腔粘膜上的这些反应尤为明顯。此時可能發生特異性的剝脫性舌炎。舌背的絲狀乳头全部或部分消失,而变得平滑、發紅,宛如被燒灼过似的。舌尖亦常被侵及,呈現持久性疼痛,而这种疼痛並不經常决定於舌部病变的部位及面積。这些現象都可統称为“青
The efficacy of oral administration of penicillin has long been certain. However, oral mucosa is very sensitive to penicillin in some cases. Penicillin (and streptomycin) can cause a wide variety of allergic manifestations (hives, exfoliative dermatitis). These reactions on the oral mucosa are particularly pronounced when “topical” penicillin tablets and other topical applications. Specific exfoliative glossitis may occur at this time. The lingual nipples of the tongue disappear in whole or in part and become smooth and red, as if burned. Tongue tip is also often invaded, showing persistent pain, and this pain does not often determine the location and area of tongue lesions. These phenomena can be collectively referred to as "green