论文部分内容阅读
本文从123例肝病患者肝穿的资料(其中死后肝穿107例,活检16例)中选择较完整资料的慢性重型肝炎66例,着重对其病变和病因、发病机理进行了研究。其病变特征是在慢性肝病的病变基础上发生肝细胞大块或亚大块坏死,从而分为坏死后肝硬变型、活动性小结节型肝硬变型、重度慢性活动性肝炎型及胆汁性肝硬变型四种类型。其中从坏死后肝硬变发展者最多,活动性小结节型肝硬变及重度慢活肝发展为本病者次之,从胆汁性肝硬变发生的又次之。采用免疫组化检测肝组织及免疫血清检查,发现66例慢性重型肝炎均为HBV阳性反应。提示武汉地区本病的病因主要为乙肝病毒引起上述慢性肝病后发展而来,机体免疫功能改变为本病发展的主要内在因素。
In this paper, 66 patients with chronic severe hepatitis were selected from 123 liver biopsy specimens (including 107 post-mortem liver biopsies and 16 biopsy specimens), and their pathological changes, etiopathogenisis and pathogenesis were studied. The lesion is characterized by chondriosis or subunit necrosis of hepatocytes on the basis of the lesion of chronic liver disease, which is divided into post-necrosis cirrhosis, active small nodular cirrhosis, severe chronic active hepatitis and biliary Four types of cirrhosis. Among them, the most developed cirrhotic patients after necrosis, small active nodular cirrhosis and severe slow-living liver development followed by the disease, followed by the occurrence of biliary cirrhosis. Immunohistochemical detection of liver tissue and immune sera found that 66 cases of chronic severe hepatitis were positive for HBV. It is suggested that the main cause of this disease in Wuhan is the development of the above-mentioned chronic liver disease caused by hepatitis B virus, and the change of the immune function of the body is the main internal factor for the development of this disease.