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合成了Cu(Ⅱ),Ni(Ⅱ),Co(Ⅱ),Mn(Ⅱ),Zn(Ⅱ)和Cd(Ⅱ)的乙基3-(2-氨硫化亚肼基)-2-(羟胺基)丁烯酸酯配合物(H2L)并用元素分析,DTA热分析,IR,UV-Vis,1H-NMR,质谱,顺磁共振以及磁矩,电导率测量等对合成的配合物进行表征。摩尔电导率测量结果证明合成的配合物为非电解质。光谱数据表明配体分别表现为一元的三齿配体,一元的二齿配体,中性的二齿配体,中性的三齿配体,一元的四齿配体或二元的四齿配体通过席夫碱的氮原子,氨基硫脲中的氮原子,肟中的氮原子和硫酮中的硫原子与金属离子键合生成围绕金属离子的四面体或平面正方形构型。固态Cu(Ⅱ)(2),(3),(4)和(5)的配合物顺磁共振谱表明其为轴向对称,但(10~15)的配合物却为各向异性。配体和配合物(2),(3),(10),(13),(16)和(19)由于它们对乳腺癌(MCF-7细胞系)和肝癌(HePG-2细胞系)的抑制作用而表现出潜在的抗癌活性。
Synthesis of ethyl 3- (2-aminosulfhydrazono) -2- (hydroxylamine) with Cu (Ⅱ), Ni (Ⅱ), Co (Ⅱ), Mn (Ⅱ), Zn (Ⅱ) and Cd (Ⅱ) (H2L) was synthesized and characterized by elemental analysis, DTA thermal analysis, IR, UV-Vis, 1H-NMR, mass spectrum, paramagnetic resonance and magnetic moment and conductivity measurements. The results of molar conductivity measurements show that the synthesized complexes are non-electrolytes. Spectral data show that the ligands are represented by monobasic tridentate ligands, monobasic bidentate ligands, neutral bidentate ligands, neutral tridentate ligands, monobasic tetradentate ligands or binary tetradentate The ligand binds to the metal ion via the nitrogen atom of the Schiff base, the nitrogen atom in thiosemicarbazone, the nitrogen atom in the oxime, and the sulfur atom in the thioketone to form a tetrahedral or planar square configuration around the metal ion. The paramagnetic resonance spectra of the solid Cu (Ⅱ) (2), (3), (4) and (5) show that it is axially symmetric but the complex of (10-15) is anisotropic. Ligands and complexes (2), (3), (10), (13), (16) and (19) due to their effect on breast cancer (MCF-7 cell line) and liver cancer (HePG-2 cell line) Inhibition and showed potential anticancer activity.