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目的分析深圳市乙肝免疫预防的成效,为制定乙肝预防控制策略提供科学依据。方法利用乙肝血清流行病学调查结果及历年深圳市乙肝发病数据,采用成本-效益分析方法综合评价深圳市1993-2013年乙肝免疫预防实施成效。结果据估算,深圳市在1993-2013年间共接种10 881 126剂次乙肝疫苗,通过接种乙肝疫苗避免了1 400902例HBs Ag阳性、74 354例急性乙肝、5 577例慢性乙肝、1 032例肝硬化和108例肝癌的发生,产生的净效益为46.91亿元,成本效益比为1∶15.54。结论深圳市在1993-2013年间通过实施乙肝免疫预防为主的综合防制措施取得了显著的经济和社会效益,可以为其他疾病的防控及成本-效益的评价提供参考。
Objective To analyze the effect of hepatitis B immunization prevention in Shenzhen and provide a scientific basis for formulating hepatitis B prevention and control strategy. Methods Based on the results of hepatitis B epidemiology survey and data of hepatitis B incidence in Shenzhen over the years, the effectiveness of hepatitis B immunization prevention in Shenzhen from 1993 to 2013 was evaluated by cost-benefit analysis. Results It was estimated that a total of 10 881 126 doses of hepatitis B vaccine were administered in Shenzhen from 1993 to 2013 and 1 400 902 HBs Ag positives were avoided by inoculation of hepatitis B vaccine. 74 354 acute hepatitis B, 5 577 chronic hepatitis B and 1032 liver Hardening and the occurrence of 108 cases of HCC resulted in a net benefit of 4.691 billion yuan and a cost-benefit ratio of 1:15.54. Conclusion Shenzhen has obtained significant economic and social benefits through the implementation of comprehensive prevention and control measures based on hepatitis B immunization during 1993-2013, which can provide reference for prevention and control of other diseases and cost-benefit evaluation.