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偏头痛的确切发病机理迄今不明。经典学说认为,偏头痛发作与脑血管痉挛以及随之而来的头外血管扩张有关。Mccarthy T等认为是某种尚未查清的物质突然引起的一系列生理现象,如血小板凝集,五羟色胺和血栓烷A_2的释出,前列腺素的激化,导致局部血管收缩和无菌炎症,继之以反应性的脑血管扩张,因而可使疼痛敏感的小动脉发生具有搏动特点的偏头痛。也有人认为可能由于脑内前列腺素突然合成过多所造成。人注入前列腺素可导致单侧头痛、恶心、呕吐;前列腺素的类似化合物2k—26,374更可产生剧烈症状头痛,历3天之久,这些都与偏头痛症状相似。另外一些研究发现;
The exact pathogenesis of migraine has so far been unknown. The classic doctrine states that migraine attacks are associated with cerebral vasospasm and consequent vasodilation of the head. Mccarthy T et al. Identified a series of physiological phenomena such as platelet aggregation, the release of serotonin and thromboxane A 2, the exacerbation of prostaglandins, resulting in local vasoconstriction and aseptic inflammation, which are suddenly caused by some unknown substance followed by Reactive cerebrovascular dilatation, which can make the pain-sensitive arterioles have migraine characteristics pulsatile. Some people think that may be due to sudden synthesis of prostaglandins in the brain caused by too much. Prostaglandin infusion can cause unilateral headache, nausea, vomiting; similar compounds 2k-26,374 prostaglandins produce more severe symptoms of headache, which lasted 3 days, these are similar to migraine symptoms. Other studies found that