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目的观察玻璃体腔内注射曲安奈德联合激光光凝治疗糖尿病黄斑水肿的疗效并进行分析。方法30例41眼经眼底检查、荧光素眼底血管照影(FFA)检查确诊的糖尿病黄斑水肿患者21眼行玻璃体腔内注射曲安奈德(TA)联合激光光凝,20眼单纯激光光凝,随访6个月,观察治疗前后患眼视力、眼底情况、眼压以及眼底荧光素血管照影的变化。结果联合治疗组治疗后平均视力为0.36±0.21,与治疗前(0.10±0.07)比较,P<0.001,差异有统计学意义,水肿减轻17眼(80.95%);单纯光凝组治疗后平均视力为0.12±0.09,与治疗前(0.11±0.07)比较,P>0.05,差异无统计学意义;水肿减轻7眼(35.00%)。两组水肿减轻差异显著(χ2=8.91,P<0.005)。结论激光光凝治疗糖尿病黄斑水肿时联合玻璃体腔内注射曲安奈德可促进水肿吸收和视力改善,且安全方便,是一种有效可行的方法。
Objective To observe the efficacy of intravitreal injection of triamcinolone acetonide combined with laser photocoagulation in the treatment of diabetic macular edema and analyze the results. Methods Seventy eyes of 41 eyes were examined by funduscopy and 21 eyes of diabetic macular edema diagnosed by fluorescein fundus angiography (FFA) underwent intravitreal injection of triamcinolone acetonide combined with laser photocoagulation and 20 eyes of laser photocoagulation alone. The patients were followed up for 6 months. The changes of ocular vision, fundus, intraocular pressure and fundus fluorescein angiography were observed before and after treatment. Results The average visual acuity of the combined treatment group after treatment was 0.36 ± 0.21, which was significantly lower than that before treatment (0.10 ± 0.07), P <0.001, and the edema was relieved in 17 eyes (80.95%). The mean visual acuity 0.12 ± 0.09, P> 0.05 before treatment (0.11 ± 0.07). There was no significant difference between the two groups in edema and edema in 7 eyes (35.00%). There was significant difference between the two groups (χ2 = 8.91, P <0.005). Conclusion Laser photocoagulation combined with intravitreal injection of triamcinolone acetonide in the treatment of diabetic macular edema can promote edema absorption and improve visual acuity, and is safe and convenient. It is an effective and feasible method.