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目的探讨早期发现卵巢恶性肿瘤的手段及其预后,为该方法在临床上推广应用提供科学依据。方法应用微创性针状腹腔镜(外径3mm),观察43例卵巢肿块≤5cm女性的盆腹腔情况,直视下放大数倍视野选择活检部位,贴近卵巢表面,探查剖腹无法看清部位如横膈、肝、胃等。收集盆腔腹水或冲洗液,取可疑组织送病理检查。免疫组织化学分析组织标本增殖细胞核抗原(PCNA)和P53基因蛋白表达水平。结果43例患者中发现卵巢成熟畸胎瘤12例,卵巢黄体3例,卵巢子宫内膜异位囊肿8例,输卵管积水6例,卵巢浆液性囊性瘤5例,卵巢粘液性囊性瘤2例,卵巢冠囊肿4例,卵巢交界性肿瘤1例,卵巢浆液性上皮癌2例。2例卵巢浆液性上皮癌组织标本PCNA和P53基因蛋白阳性。结论应用针状腹腔镜对卵巢小肿块进行检查是早期发现卵巢恶性肿瘤的有效手段。
Objective To explore the means and prognosis of early detection of ovarian cancer and provide a scientific basis for its application in clinic. Methods The minimally invasive needle-like laparoscopy (diameter 3mm) was used to observe the pelvic and abdominal cavity of 43 women with ovarian masses ≤5cm. The biopsy site was enlarged by several times visual field, close to the surface of the ovary, and the caesarean section could not be seen Diaphragm, liver, stomach and so on. Collect pelvic ascites or irrigation fluid, take suspicious tissues sent to pathological examination. Immunohistochemical analysis of tissue samples of proliferating cell nuclear antigen (PCNA) and P53 gene protein expression levels. Results In 43 cases, 12 cases of mature ovarian teratoma, 3 cases of luteal ovary, 8 cases of ovarian endometriosis, 6 cases of hydrosalpinx, 5 cases of ovarian serous cystadenoma, 2 cases, 4 cases of ovarian crown cysts, 1 case of borderline ovarian tumors, 2 cases of ovarian serous epithelial carcinoma. 2 cases of ovarian serous epithelial cancer tissue samples PCNA and P53 gene protein positive. Conclusion The application of acupuncture laparoscopic examination of small ovarian tumors is an effective means of early detection of ovarian cancer.