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HLA(human leukocyte antigen)同疾病相关的研究已在世界各地开展。目前已知与 HLA 相关的疾病有200多种,最突出的是强直性脊柱炎同 HLA-B_(27)相关,频率为95%,有一定的诊断价值。涉及皮肤病的也有十数种。如:(1)银屑病:研究过的人种群中寻常型银屑病皆同 HLA—B_(13)、B_(17)相关,相关危险率(relative risk 简称 RR)为3～5。也有报告同 B_(37)呈强相关,RR 达19.67。近来报告并同 CW_6DR_7相关。但是关节型银屑病主要同 B_(27)相关,RR 达10.68。(2)Re-iter 氏病:与 HLA-B_(27)呈强相关,RR 高达37。本病往往有关节炎症状,联系到强直性脊柱炎,推测 HLA—B_(27)可能控制了中枢性关节炎症状。(3)疱疹样皮炎:同 HLA-B_8强相关,RR 为8～11,少数报告与 DW_3相关,RR 竟达15～41。(4)白塞氏综合征同HLA-B_5相关,RR 为4.3～6.6。上述皮肤病与 HLA 相关比较显著。此外,还有报告认为寻常型及落叶型天疱疮、大疱性类天疱疮、
HLA (human leukocyte antigen) Disease-related research has been carried out all over the world. At present, there are more than 200 known diseases related to HLA. The most prominent is that ankylosing spondylitis is associated with HLA-B_ (27) at a frequency of 95%, which is of diagnostic value. There are also dozens of skin diseases. Such as: (1) Psoriasis: The psoriasis vulgaris in the studied population is related to HLA-B_ (13), B_ (17), the relative risk (RR) of 3 to 5. There was also a strong correlation between the report and B_ (37), with an RR of 19.67. Recently reported and related to CW_6DR_7. However, joint psoriasis is mainly associated with B_ (27), with a RR of 10.68. (2) Re-iter’s disease: strongly correlated with HLA-B_ (27), with a RR of 37. The disease is often related to arthritis symptoms, ankylosing spondylitis, speculated that HLA-B_ (27) may control the symptoms of central arthritis. (3) herpetic dermatitis: strongly associated with HLA-B_8, RR 8 to 11, a small number of reports related to DW_3, RR actually up to 15 to 41. (4) Behcet’s syndrome is associated with HLA-B_5, RR is 4.3 ~ 6.6. The skin disease and HLA-related more significant. In addition, there are reports that vulgaris and pemphigus pemphigus, bullous pemphigoid,