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人体肝癌的发生,虽然在流行病学方面提示肝癌与乙型肝炎病毒(HBV)和黄曲霉毒素B_1(AFB_1)等因素有关,但迄今为止,尚无证明HBV和AFB_1引发人体肝癌的直接证据。其中重要原因是缺少直接研究人体肝癌癌变的模型和手段。鸭乙型肝炎病毒(DHBV)与人乙型肝炎病毒(HBV)、土拨鼠乙型肝炎病毒(WHV)以及地松鼠乙型肝炎病(GSHV)同属嗜肝DNA病毒科(Hepadra-
Although human hepatocellular carcinoma is epidemiologically implicated in hepatocellular carcinoma (HCC) in relation to hepatitis B virus (HBV) and aflatoxin B1 (AFB1), so far no direct evidence has been given that HBV and AFB1 cause human liver cancer. One important reason is the lack of direct study of human liver cancer models and methods. Duck hepatitis B virus (DHBV) and human hepatitis B virus (HBV), woodchuck hepatitis B virus (WHV) and ground squirrel hepatitis B (GSHV) belong to the Hepadra-