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为了研究释放左旋十八甲基炔诺酮（２０μｇ／天）宫内节育器（ＬＮＧ－ＩＵＤ－２０）对子宫内膜细胞ＤＮＡ含量的影响。将置器后子宫内膜剪碎后涂片，Ｆｅｕｌｇｅｎ染色，用显微分光光度计测量内膜单细胞核ＤＮＡ含量。结果显示，放置ＩＵＤ后内膜细胞ＤＮＡ含量显著下降（Ｐ＜０．００１）。鉴于低释放量的（２μｇ／天）ＬＮＧ－ＩＵＤ（ＬＮＧ－ＩＵＤ－２）并不影响内膜细胞的ＤＮＡ含量。认为，ＬＮＧ－ＩＵＤ对内膜增殖活性的影响同释放量密切相关，而且推断对内膜活性的抑制程度与ＩＵＤ的临床表现密切相关
In order to investigate the effect of releasing levonorgestrel (20 μg / day) intrauterine device (LNG-IUD-20) on the DNA content of endometrial cells. The endometrial mucosa was resected and smeared with Feulgen and the content of single nucleus intima was measured with a spectrophotometer. The results showed that the DNA content of endometrial cells was significantly decreased after IUD placement (P <0.001). In view of the low level of release (2 μg / day) LNG-IUD (LNG-IUD-2) did not affect the DNA content of intima cells. It is believed that the effect of LNG-IUD on intimal proliferative activity is closely related to the amount released, and it is inferred that the degree of inhibition of intimal activity is closely related to the clinical manifestations of IUD