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目的探讨健康男性血浆kisspeptin与更年期发生的关系。方法对上海市宝山区99名健康志愿者进行PADAM问卷调查、外周血激素测定,分析血浆kisspeptin与年龄、更年期发生及激素间的关系。结果成年男性99名血浆kisspeptin随年龄增加而增长,PADAM症状阳性率也随年龄增高。PADAM症状阳性组与阴性组间年龄差异有统计学意义(P<0.01),而kisspeptin差异无统计学意义(P>0.05)。血浆kisspeptin与年龄(P<0.01)、雌二醇(E2)(P=0.039)密切相关,年龄是血浆kisspeptin变化的重要影响因素(P=0.004)。结论血浆kisspeptin与更年期发生无明显关系,提示成年后kisspeptin在HPG轴中的作用可能不及青春期启动时重要。
Objective To investigate the relationship between plasma kisspeptin and menopause in healthy men. Methods A total of 99 healthy volunteers from Baoshan District of Shanghai were investigated by PADAM questionnaire and peripheral blood hormone levels. The relationship between plasma kisspeptin and age, menopause and hormone was analyzed. Results The plasma kisspeptin in 99 male patients increased with age, and the positive rate of PADAM symptoms also increased with age. There were significant differences in age between PADAM positive group and negative group (P <0.01), but no significant difference in kisspeptin (P> 0.05). Plasma kisspeptin is closely related to age (P <0.01) and estradiol (E2) (P = 0.039). Age is an important factor in the change of plasma kisspeptin (P = 0.004). Conclusion There is no significant relationship between kisspeptin and menopause, suggesting that the role of kisspeptin in HPG axis may not be as important as the onset of puberty in adulthood.